Biological Activity
Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
Technical Data
| M. Wt | 252.74 |
| Formula | C9H20N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 137361-05-8 |
| PubChem ID | 447180 |
| InChI Key | AOMXURITGZJPKB-ZETCQYMHSA-N |
| Smiles | N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.27 | 100 | |
| water | 21.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.78 mL | 39.57 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.91 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID: 11404282
Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID: 9397167
Keywords: Nw-Propyl-L-arginine hydrochloride, supplier, selective, inhibitors, inhibits, nNOS, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, Nomega-Propyl-L-arginine, hydrochloride, nNOS, nNOS, Tocris Bioscience
