Biological Activity
Prostaglandin E2 and F2α receptor agonist. Naturally-occurring prostaglandin and potent vasoconstrictor. Induces cardiomyocyte hypertrophy in vitro. Exhibits luteolytic activity.
Technical Data
| M. Wt | 475.62 |
| Formula | C20H34O5.C4H11NO3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 38562-01-5 |
| PubChem ID | 5282415 |
| InChI Key | IYGXEHDCSOYNKY-RZHHZEQLSA-N |
| Smiles | O[C@@H]1[C@H](C/C=CCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1.NC(CO)(CO)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.56 | 100 | |
| ethanol | 47.56 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 475.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.1 mL | 10.51 mL | 21.03 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.21 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.1 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Samuelsson et al (1978) Prostaglandins and throboxanes. Annu.Rev.Biochem. 47 997 PMID: 209733
Girsh and Dekel (2002) Involvement of endothelin-1 and its receptors in PGF2α-induced luteolysis in the rat. Mol.Reprod.Dev. 63 71 PMID: 12211063
Lai et al (1996) Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo. Am.J.Physiol. 271 2197 PMID:
Keywords: Prostaglandin F2alpha, supplier, Dinoprost, tromethamine, salt, prostaglandin, E2, F2a, F2alpha, recepor, agonist, PGF2a, agonists, vasoconstrictor, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
