BiologicalActivity
Cyclin-dependentkinaseinhibitor.IC50valuesare4,70,35,850and75nMforcdc2/cyclinB,cdk2/cyclinA,cdk2/cyclinE,cdk4/cyclinD1andcdk5-p35respectively.ReversIBLyarrestssynchronisedcellsinG1andG2,andinhibitscellproliferationandcelldeath.
LicensingInformation
SoldunderlicensefromtheRegentsoftheUniversityofCalifornia
CompoundLibraries
PurvalanolAisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 388.9 |
| Formula | C19H25ClN6O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 212844-53-6 |
| PubChemID | 456214 |
| InChIKey | PMXCMJLOPOFPBT-HNNXBMFYSA-N |
| Smiles | ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 19.45 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight388.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.86mL | 25.71mL |
| 5mM | 0.51mL | 2.57mL | 5.14mL |
| 10mM | 0.26mL | 1.29mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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