Biological Activity
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.
Technical Data
M. Wt | 164.28 |
Formula | C5H12N2S2 |
Storage | Store at RT |
CAS Number | 5108-96-3 |
PubChem ID | 73343 |
InChI Key | MDDIUTVUBYEEEM-UHFFFAOYSA-N |
Smiles | [NH4+].[S-]C(N1CCCC1)=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 16.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 164.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 6.09 mL | 30.44 mL | 60.87 mL |
5 mM | 1.22 mL | 6.09 mL | 12.17 mL |
10 mM | 0.61 mL | 3.04 mL | 6.09 mL |
50 mM | 0.12 mL | 0.61 mL | 1.22 mL |
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References
References are publications that support the products' biological activity.
Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883 PMID: 7986199
Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163 PMID: 7513157
Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83 PMID: 7533726
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