Biological Activity
Antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPER) receptors.
Technical Data
| M. Wt | 302.24 |
| Formula | C15H10O7 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 117-39-5 |
| PubChem ID | 5280343 |
| InChI Key | REFJWTPEDVJJIY-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 302.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.31 mL | 16.54 mL | 33.09 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.62 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.31 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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References
References are publications that support the products' biological activity.
Cermak et al (2002) The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183 PMID: 11877325
Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583 PMID: 6311542
Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227 PMID: 6091650
Saponara et al (2002) Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819 PMID: 11934824
Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952 PMID: 8069862
Merck Index 12 8216 PMID:
Keywords: Quercetin, supplier, Non-Selective, PI, 3-kinase, inhibitors, inhibits, GPR30, agonists, non-selective, 3-Kinase, PI3K, Akt, Signaling, Signalling, PIP2, Inositol, Lipids, cAMP, Receptors, Estrogen, receptors, Phosphoinositide, Kinases, GPER, Inositol, Lipids, PI, 3-Kinase, Estrogen, (GPER), Receptors, IRE1, PI, 3-Kinase, Tocris Bioscience
