Biological Activity
Potent and selective FPR2 agonist (EC50 = 40 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.
Technical Data
| M. Wt | 445.51 |
| Formula | C26H27N3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 786706-21-6 |
| PubChem ID | 11751175 |
| InChI Key | XORVAHQXRDLSFT-UHFFFAOYSA-N |
| Smiles | O=C1N(NC(C2=CC=C(OCCCC)C=C2)=O)C(C3=CC=C(OC)C=C3)NC4=CC=CC=C41 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.55 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 445.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.22 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID: 17652444
Corminboeuf et al (2014) FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 58 537 PMID: 25365541
Keywords: Quin C1, supplier, QuinC1, potent, selective, agonists, agonism, FPR2, FPRL1, formyl, peptide, receptor-like, 1, inflammation, anti-inflammatory, Formyl, Peptide, Receptors, Formyl, Peptide, Receptors, Tocris Bioscience
