Biological Activity
Dopamine D2 and D3 receptor agonist; Ki values are 5.7 and 3.4 nM respectively.
Licensing Information
Sold with the permission of Eli Lilly and Company
Technical Data
| M. Wt | 319.27 |
| Formula | C14H22N4.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 97548-97-5 |
| PubChem ID | 68728 |
| InChI Key | WDEMLQIGYYLRRX-OWVUFADGSA-N |
| Smiles | [H][C@]23[C@@](CCCN3CCC)([H])CC1=NC(N)=NC=C1C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.98 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Foreman et al (1989) Preclinical studies on quinelorane, a potent and highly selective D2-dopaminergic agonist. J.Pharmacol.Exp.Ther. 250 227 PMID: 2526214
Eaton et al (1994) Effects of the selective dopaminergic D2 agonist quinelorane on the activity of dopaminergic and noradrenergic neurons projecting to the diencephalon of the rat. J.Pharmacol.Exp.Ther. 268 645 PMID: 7906734
Flietstra and Levant (1998) Comparison of D2 and D3 dopamine receptor affinity of dopaminergic compounds in the rat brain. Life Sci. 62 1825 PMID: 9600324
Keywords: Quinelorane hydrochloride, supplier, D2, D3, agonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, LY163502, LY, 163502, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
