Biological Activity
Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
Licensing Information
Sold with the permission of Eli Lilly and Company
Compound Libraries
(-)-Quinpirole hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 255.79 |
| Formula | C13H21N3.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 85798-08-9 |
| PubChem ID | 55397 |
| InChI Key | HJHVRVJTYPKTHX-HTMVYDOJSA-N |
| Smiles | Cl.[H][C@]12CCCN(CCC)[C@]1([H])CC1=CNN=C1C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.39 | 25 | |
| water | 25.58 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 255.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.91 mL | 19.55 mL | 39.09 mL |
| 5 mM | 0.78 mL | 3.91 mL | 7.82 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.91 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Levant et al (1996) Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J.Pharmacol.Exp.Ther. 278 145 PMID: 8764345
Seeman and Van Tol (1994) Dopamine receptor pharmacology. Trends Pharmacol.Sci. 15 264 PMID: 7940991
Sullivan et al (1998) Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience 83 781 PMID: 9483561
Keywords: (-)-Quinpirole hydrochloride, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
