Biological Activity
Selective 5-HT3 receptor agonist. Also displays antagonist activity at peripheral 5-HT3 receptors. [3H]-Quipazine labels 5-HT3 sites in the cortical membranes.
Technical Data
| M. Wt | 445.43 |
| Formula | C13H15N3.2C4H4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 150323-78-7 |
| PubChem ID | 6420043 |
| InChI Key | VAOSOCRJSSWBEQ-SPIKMXEPSA-N |
| Smiles | OC(=O)C=C/C(O)=O.OC(=O)C=C/C(O)=O.C1CN(CCN1)C1=NC2=C(C=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.54 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 445.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.23 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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References
References are publications that support the products' biological activity.
Ireland and Tyers (1987) Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br.J.Pharmacol. 90 229 PMID: 3814920
Peroutka and Hamik (1988) [3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes. Eur.J.Pharmacol. 148 297 PMID: 3378579
Sharif et al (1991) Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. Br.J.Pharmacol. 102 919 PMID: 1830236
Keywords: Quipazine dimaleate, supplier, 5-HT3, agonists, Serotonin, Receptors, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
