BiologicalActivity
PositiveallostericmodulatorandallostericagoNISTofthehumancalcium-sensingreceptor(hCaSR).Exhibitscalcimimeticactivity.HastheABIlitytorestorefunctiontohCaSRmutantsthatcausefamilialhypocalciurichypercalcemia(FHH)andneonatalseverehyperparathyroidism(NSHPT).Exertsasuppressiveeffectonparathyroid(PT)hormonesecretion;inhibitsPTcellproliferationinratswithrenalinsufficiency.
CompoundLibraries
R568hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 340.29 |
| Formula | C18H22ClNO.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 177172-49-5 |
| PubChemID | 158796 |
| InChIKey | YJXUXANREVNZLH-PFEQFJNWSA-N |
| Smiles | ClC(C=CC=C2)=C2CCCN[C@H](C)C1=CC=CC(OC)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.03 | 100 | |
| ethanol | 34.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight340.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.94mL | 14.69mL | 29.39mL |
| 5mM | 0.59mL | 2.94mL | 5.88mL |
| 10mM | 0.29mL | 1.47mL | 2.94mL |
| 50mM | 0.06mL | 0.29mL | 0.59mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
