Biological Activity
Inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
Technical Data
| M. Wt | 380.77 |
| Formula | C16H8ClF3N4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 303997-35-5 |
| PubChem ID | 1486608 |
| InChI Key | SUUMKHOVGVYGOP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.62 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 380.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.13 mL | 26.26 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.25 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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References
References are publications that support the products' biological activity.
Gururaja et al (2007) A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 14 1105 PMID: 17961823
King et al (2013) TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 542 92 PMID: 23499961
Keywords: R 7050, supplier, R7050, tumor, necrosis, TNFa, TNFalpha, TNFα, inhibitors, inhibits, signaling, cytokines, receptors, Cytokine, Receptors, Cytokine, Receptors, Tocris Bioscience
