Biological Activity
Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.
Technical Data
| M. Wt | 1014.2 |
| Formula | C46H71N21O6 |
| Sequence |
RRRRWW (Modifications: Trp-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 206350-79-0 |
| PubChem ID | 90479804 |
| InChI Key | MGQHBRDQUJRCLN-UJARKJSPSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1014.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.99 mL | 4.93 mL | 9.86 mL |
| 5 mM | 0.2 mL | 0.99 mL | 1.97 mL |
| 10 mM | 0.1 mL | 0.49 mL | 0.99 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981 PMID: 12023528
Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131 PMID: 10996311
Keywords: L-R4W2, supplier, TRPV1, antagonists, peptide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, TRPV, TRPV, Tocris Bioscience
