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Tocris Bioscience(优势品牌)
主营:主营:分子类,蛋白类,抗体类,生化类试剂
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当前位置: 首页 > 产品中心 > Other_enzymes > Tocris/RAF 265/6015/10/10 mg
商品详细Tocris/RAF 265/6015/10/10 mg
Tocris/RAF 265/6015/10/10 mg
Tocris/RAF 265/6015/10/10 mg
商品编号: 6015/10
品牌: Tocris Bioscience
市场价: ¥4300.00
美元价: 2580.00
产地: 美国(厂家直采)
公司:
产品分类: 其它酶
公司分类: Other_enzymes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:RafkinaseandVEGFR-2inhibitor
AlternativeNames:CHIR265
ChemicalName:1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

RafkinaseandVEGFR-2inhibitor.Inhibitsc-Raf,wildtypeB-RafandmutantB-Raf(V600E).Cytotoxicincertainmelanomacellslines.EffectsenhancedbyproteinkinaseD3inhibition,preventingreactivationofMAPKsignalingandincreasingcaspaseactivity.Orallybioavailable.

TechnicalData

M.Wt518.41
FormulaC24H16F6N6O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber927880-90-8
PubChemID11656518
InChIKeyYABJJWZLRMPFSI-UHFFFAOYSA-N
SmilesCN1C(NC2=CC=C(C=C2)C(F)(F)F)=NC3=CC(OC4=CC=NC(C5=NC=C(C(F)(F)F)N5)=C4)=CC=C13

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO51.84100
ethanol10.3720

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight518.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.93mL9.64mL19.29mL
5mM0.39mL1.93mL3.86mL
10mM0.19mL0.96mL1.93mL
50mM0.04mL0.19mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet