Biological Activity
Cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.
Technical Data
| M. Wt | 1131.37 |
| Formula | C57H70N12O9S2 |
| Sequence |
FCYWKVCW (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 103222-11-3 |
| PubChem ID | 6918026 |
| InChI Key | SWXOGPJRIDTIRL-DOUNNPEJSA-N |
| Smiles | [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.20 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1131.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 5 mM | 0.18 mL | 0.88 mL | 1.77 mL |
| 10 mM | 0.09 mL | 0.44 mL | 0.88 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release. Life Sci. 41 1011 PMID: 2886886
Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476
Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356 PMID: 12878607
Keywords: RC 160, supplier, Somatostatin, sst, Receptors, RC160, Vapreotide, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
