Biological Activity
Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
Technical Data
| M. Wt | 433.42 |
| Formula | C15H27N7O8 |
| Sequence | RGDS |
| Storage | Desiccate at -20°C |
| CAS Number | 91037-65-9 |
| PubChem ID | 107775 |
| InChI Key | NNRFRJQMBSBXGO-CIUDSAMLSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 433.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.54 mL | 23.07 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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References
References are publications that support the products' biological activity.
Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733 PMID: 15522882
Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18 PMID: 19272161
Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551 PMID: 19276073
Keywords: RGDS peptide, supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules, Cell, Adhesion, Molecules, Integrins, Integrins, Tocris Bioscience
