Biological Activity
Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.
Compound Libraries
RN 1 dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 452.42 |
| Formula | C23H29N3O2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1781835-13-9 |
| PubChem ID | 90488995 |
| InChI Key | WMHAFZOOUBPQRX-VSIGASKDSA-N |
| Smiles | O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.05 | 20mM with gentle warming | |
| water | 9.05 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 452.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Neelamegam et al (2012) Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 3 120 PMID: 22754608
Keywords: RN 1 dihydrochloride, supplier, RN1, dihydrochloride, LSD1, lysine-specific, demethylase, 1, histone, demethylases, monoamine, oxidases, MAOs, inhibitors, inhibits, selective, Histone, Demethylases, Histone, Demethylases, Tocris Bioscience
