Biological Activity
A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data
| M. Wt | 590.56 |
| Formula | C26H36ClN3O6S.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 167710-87-4 |
| PubChem ID | 19081934 |
| InChI Key | QSMYZGMJSGUWPM-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC(OC)=CC(COC2=CC(N)=C(Cl)C=C2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.06 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 590.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.69 mL | 8.47 mL | 16.93 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.39 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.69 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Eglen et al (1995) Central 5-HT4 receptors TiPS 16 391 PMID: 8578609
Hegde (1995) RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br.J.Pharmacol. 115 1087 PMID: 7582507
Keywords: RS 39604 hydrochloride, supplier, 5-HT4, antagonist, Serotonin, Receptors, 5-Hydroxytryptamine, RS39604, hydrochloride, 5-HT4, Receptors, 5-HT4, Receptors, Tocris Bioscience
