Biological Activity
A potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo, with an intrinsic activity relative to 5-HT of 0.5.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data
| M. Wt | 389.36 |
| Formula | C19H29ClN2O2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 168986-60-5 |
| PubChem ID | 9800491 |
| InChI Key | XVBGLZNYWUUAFF-UHFFFAOYSA-N |
| Smiles | Cl.CCCCN1CCC(CCC(=O)C2=CC(Cl)=C(N)C=C2OC)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.73 | 25mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 389.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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References
References are publications that support the products' biological activity.
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295
Keywords: RS 67333 hydrochloride, supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67333, hydrochloride, 5-HT4, Receptors, 5-HT4, Receptors, Tocris Bioscience
