Biological Activity
A potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data
| M. Wt | 454.41 |
| Formula | C18H28ClN3O4S.HCl |
| Storage | Store at RT |
| CAS Number | 168986-61-6 |
| PubChem ID | 133075 |
| InChI Key | GFWKWEHKHLTRRF-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 80 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 454.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 11 mL | 22.01 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295
Keywords: RS 67506 hydrochloride, supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, 5-HT4, Receptors, 5-HT4, Receptors, Tocris Bioscience
