Biological Activity
Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.
Technical Data
| M. Wt | 658.76 |
| Formula | C34H43F5O5S |
| Storage | Store at +4°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 151555-47-4 |
| PubChem ID | 6918261 |
| InChI Key | SDCUWFRXMLQNCS-LFAPAAFUSA-N |
| Smiles | OC1=CC=C2C(CC[C@]3([H])[C@@]([H])2[C@@H]([C@]5=CC=C(OCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 65.88 | 100 | |
| ethanol | 65.88 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 658.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.52 mL | 7.59 mL | 15.18 mL |
| 5 mM | 0.3 mL | 1.52 mL | 3.04 mL |
| 10 mM | 0.15 mL | 0.76 mL | 1.52 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263 PMID: 9443403
Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449 PMID:
Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in estradiol-dependent cancers. J.Steroid Molec.Biol. 92 1 PMID:
Keywords: RU 58668, supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience
