Biological Activity
Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).
Compound Libraries
RWJ 50271 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 410.41 |
| Formula | C18H17F3N4O2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 162112-37-0 |
| PubChem ID | 9953357 |
| InChI Key | HOFGTYCLOKDAES-UHFFFAOYSA-N |
| Smiles | CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.04 | 100 | |
| ethanol | 4.1 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 410.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.18 mL | 24.37 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Sanfilippo et al (1995) Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 38 1057 PMID: 7707308
Keywords: RWJ 50271, supplier, RWJ50271, inhibitors, inhibits, LFA-1/ICAM-1, adhesion, sICAM, lymphocyte, function-associated, antigen-1, Integrins, Cell, Adhesion, Molecules, Integrins, Tocris Bioscience
