Biological Activity
Agonist of the α2D adrenergic receptor (Ki values are 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively).
Technical Data
| M. Wt | 202.28 |
| Formula | C11H10N2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 245744-10-9 |
| PubChem ID | 71752148 |
| InChI Key | LIHWQUZNTRDJFW-UHFFFAOYSA-N |
| Smiles | C1(SC=C2)=C2C(C3=CN=CN3)=CCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.11 | 50 | |
| ethanol | 10.11 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 202.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.94 mL | 24.72 mL | 49.44 mL |
| 5 mM | 0.99 mL | 4.94 mL | 9.89 mL |
| 10 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.99 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ross et al (2000) α2 adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J.Med.Chem. 43 765 PMID: 10753480
Amphoux et al (2010) Inhibitory and facilitatory actions of isocyanine derivatives at human and rat organic cation transporters 1, 2 and 3: a comparison to human α1- and α2-adrenoceptor subtypes. Eur.J.Pharmacol. 634 1 PMID: 20170649
Keywords: RWJ 52353, supplier, RWJ52353, agonists, alpha2D, a2d, α2d, adrenergic, receptors, adrenoceptors, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
