Biological Activity
Potent, selective α2-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).
Compound Libraries
RX 821002 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 270.72 |
| Formula | C12H14N2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 109544-45-8 |
| PubChem ID | 11957683 |
| InChI Key | IMPOOMVZVWKSAP-UHFFFAOYSA-N |
| Smiles | Cl.COC1(COC2=CC=CC=C2O1)C1=NCCN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.07 | 100 | |
| water | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 270.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.47 mL | 36.94 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.39 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Erdbrugger et al (1995) Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines. J.Pharmacol.Exp.Ther. 273 1287 PMID: 7791100
O'Rourke et al (1994) Characterisation of [3H]RX 821002 binding to alpha-2 adrenergic receptor subtypes. J.Pharmacol.Exp.Ther. 268 1362 PMID: 7908054
Trendelenburg et al (1996) Antagonists that differentiate between α2A- and α2D-adrenoceptors. Naunyn Schmiedebergs Arch.Pharmacol. 353 245 PMID: 8692278
Keywords: RX 821002 hydrochloride, supplier, Potent, selective, α2D-adrenoceptor, alpha2D-adrenoceptor, a2d-adrenoceptor, α2d-adrenergic, alpha2d-adrenergic, a2d-adrenergic, antagonists, Receptors, RX821002, hydrochloride, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
