Biological Activity
Potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM). Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM). Increases food intake in vivo.
Technical Data
| M. Wt | 1012.17 |
| Formula | C49H69N15O9 |
| Sequence |
RYYRWK (Modifications: Arg-1 = C-terminal Ac, Lys-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 200959-47-3 |
| PubChem ID | 9811889 |
| InChI Key | YROQVQIJRORFAZ-SKGSPYGFSA-N |
| Smiles | CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1012.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.99 mL | 4.94 mL | 9.88 mL |
| 5 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 10 mM | 0.1 mL | 0.49 mL | 0.99 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393
Ho et al (2000) Characterization of the ORL1 receptor on adrenergic nerve in the rat anococcygeus. Br.J.Pharmacol. 131 349 PMID: 10991930
Keywords: Ac-RYYRWK-NH2, supplier, Potent, selective, NOP, partial, agonists, peptide, Nociceptin, Receptors, ORL1, OP4, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience
