Biological Activity
Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.
Compound Libraries
Ralfinamide mesylate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 398.45 |
| Formula | C17H19FN2O2.CH3SO3H |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 202825-45-4 |
| PubChem ID | 23661379 |
| InChI Key | CHQVNINIGBRKGZ-YDALLXLXSA-N |
| Smiles | FC(C=CC=C2)=C2COC1=CC=C(CN[C@@H](C)C(N)=O)C=C1.CS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.84 | 100 | |
| water | 9.96 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 398.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.1 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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References
References are publications that support the products' biological activity.
Veneroni et al (2003) Anti-allodynic effect of NW-1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain. Pain 102 17 PMID: 12620593
Yamane et al (2007) Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats. Exp.Neurol. 208 63 PMID: 17707373
Zhang et al (2008) Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain 139 293 PMID: 18583049
Keywords: Ralfinamide mesylate, supplier, Ralfinamide, sodium, Na+, blockers, channels, NaV, tetrodotoxin, TTXr, TTXs, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
