BiologicalActivity
Antifungalandimmunosuppressant.SpecificinhibitorofmTOR(mammaliantargetofRapamycin).ComplexeswithFKBP-12andbindsmTORinhibitingitsactivity.Inhibitsinterleukin-2-inducedphosphorylationandactivationofp70S6kinase.Inducesautophagyinyeastandmammaliancelllines.DriveshPSCdifferentiationtomesendodermandbloodProgenitorcells.Alsousedasachemicaldimerizer;rapamycinandGA3-AM(Cat.No.5407)chemicallyinducIBLedimerizationsystemsareorthogonal.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofRapamycinisreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 914.18 |
| Formula | C51H79NO13 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 53123-88-9 |
| PubChemID | 5284616 |
| InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
| Smiles | O=C([C@H](C)C=C([C@@H](O)[C@@H](OC)C([C@@H]4C)=O)/C)C[C@]([C@H](C)C[C@H]2C[C@@H](OC)[C@H](O)CC2)([H])OC([C@@]1([H])N(C(C([C@@]3(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C4)C)OC)([H])O3)=O)=O)CCCC1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.71 | 50 | |
| ethanol | 18.28 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight914.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.09mL | 5.47mL | 10.94mL |
| 5mM | 0.22mL | 1.09mL | 2.19mL |
| 10mM | 0.11mL | 0.55mL | 1.09mL |
| 50mM | 0.02mL | 0.11mL | 0.22mL |
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