Biological Activity
Standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset™. Diastereomer Yohimbine hydrochloride (Cat. No. 1127) also available.
Compound Libraries
Rauwolscine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 390.91 |
| Formula | C21H26N2O3.HCl |
| Storage | Store at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 6211-32-1 |
| PubChem ID | 197067 |
| InChI Key | PIPZGJSEDRMUAW-ZKKXXTDSSA-N |
| Smiles | [H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.77 | 25mM with gentle warming | |
| ethanol | 5 | ||
| water | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 390.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.79 mL | 25.58 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Arthur et al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem.Pharmacol. 45 2337 PMID: 8517875
Hieble et al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Uhlen et al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-, and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719
Keywords: Rauwolscine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, antagonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, a2-adrenergic, Receptors, alpha-Yohimbine, hydrochloride, a-Yohimbine, hydrochloride, Corynanthidine, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
