Tocris/JH-II-127/6289/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/JH-II-127/6289/50/50 mg

Tocris/JH-II-127/6289/50/50 mg

商品编号： 6289/50

品牌： Tocris Bioscience

市场价： ¥16780.00

美元价： 10068.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveLRRK2inhibitor

ChemicalName:[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveLRRK2inhibitor(IC₅₀valuesare2.2,6.6and47.7nMforG2019S-mutant,wild-typeandA2016T-mutantLRRK2,respectively).SelectiveforLRRK2overapanelof138kinases.Brainpenetrantandorallybioavailable.

LicensingInformation

SoldunderlicensefromDana-FarberCancerInstitute.

TechnicalData

M.Wt	416.87
Formula	C₁₉H₂₁ClN₆O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1700693-08-8
Smiles	O=C(N1CCOCC1)C2=CC(OC)=C(NC3=NC(NC)=C(C(Cl)=CN4)C4=N3)C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	41.69	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight416.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.4mL	11.99mL	23.99mL
5mM	0.48mL	2.4mL	4.8mL
10mM	0.24mL	1.2mL	2.4mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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