Biological Activity
Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 mM).
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data
| M. Wt | 304.82 |
| Formula | C17H20N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 111686-79-4 |
| PubChem ID | 60510 |
| InChI Key | HYQMIUSWZXGTCC-UHFFFAOYSA-N |
| Smiles | Cl.CC(CC1=CC=CC=C1)(NC(=O)CN)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 15.24 | 50 | |
| water | 30.48 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 304.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.28 mL | 16.4 mL | 32.81 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.56 mL |
| 10 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Palmer et al (1995) Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 765 236 PMID: 7486610
Santangeli et al (2002) Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 438 63 PMID: 11906711
Subramaniam et al (1996) Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 276 161 PMID: 8558426
Keywords: Remacemide hydrochloride, supplier, NMDA, antagonists, blocks, ion, channel, allosteric, modulatory, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, AstraZeneca, FPL, 12924AA, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
