Biological Activity
Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
Compound Libraries
Resiquimod is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 314.38 |
| Formula | C17H22N4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 144875-48-9 |
| PubChem ID | 159603 |
| InChI Key | BXNMTOQRYBFHNZ-UHFFFAOYSA-N |
| Smiles | NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.44 | 100 | |
| ethanol | 15.72 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 314.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.9 mL | 31.81 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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References
References are publications that support the products' biological activity.
Dockrell and Kinghorn (2001) Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 48 751 PMID: 11733457
Miyamoto et al (2012) R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 64 331 PMID: 22358541
Wagner et al (1999) Modulation of TH1 and Th4 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol. 191 10 PMID: 9918682
Lee et al (2014) Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 37 1234 PMID: 24748512
Keywords: Resiquimod, supplier, proinflammatory, toll, like, receptors, ligands, agonists, TLR7, cytokines, interferons, interleukins, R848, R_848, myeloid-derived, suppressor, cells, MDSCs, tumor, microenvironment, R, 848, Toll-like, Receptors, Antivirals, Toll-like, Receptors, Tocris Bioscience
