BiologicalActivity
Antiviralguanosineribonucleosideanalog;misincorporatedintomRNAbyviral-dependentRNApolymerases.BindstoandredistributesmammalianeIF4Efromthenucleustothecytoplasm(Ki~0.3μMfortheactivemetabolite,ribavirintriphosphate).RepressescolonyformationofprimaryAML-M5Progenitorcells(IC50~1μM);reducesdiseaseseverityinacutemyeloidleukemia(AML).Orallyavailable.
CompoundLibraries
RibavirinisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 244.2 |
| Formula | C8H12N4O5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 36791-04-5 |
| PubChemID | 37542 |
| InChIKey | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.42 | 100 | |
| water | 24.42 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight244.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.1mL | 20.48mL | 40.95mL |
| 5mM | 0.82mL | 4.1mL | 8.19mL |
| 10mM | 0.41mL | 2.05mL | 4.1mL |
| 50mM | 0.08mL | 0.41mL | 0.82mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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