Biological Activity
Potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.
Compound Libraries
Ritanserin is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 477.57 |
| Formula | C27H25F2N3OS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 87051-43-2 |
| PubChem ID | 5074 |
| InChI Key | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
| Smiles | O=C1N3C(SC=C3)=NC(C)=C1CCN4CC/C(CC4)=C(C5=CC=C(F)C=C5)/C2=CC=C(F)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.76 | 100 | |
| ethanol | 11.94 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 477.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.47 mL | 20.94 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Janssen (1985) Pharmacology of potent and selective S2-serotonergic antagonists. J.Cardiovasc.Pharmacol. 7 S2 PMID: 2412048
Leysen et al (1985) Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 27 600 PMID: 2860558
Watanabe et al (1992) Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives. J.Med.Chem. 35 189 PMID: 1732528
Keywords: Ritanserin, supplier, Potent, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, Non-selective, 5-HT2, Non-selective, 5-HT2, Tocris Bioscience
