Biological Activity
Dual cholinesterase inhibitor (ChEI); inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Brain penetrant.
Compound Libraries
Rivastigmine tartrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 400.42 |
| Formula | C14H22N2O2.C4H6O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 129101-54-8 |
| PubChem ID | 6918078 |
| InChI Key | GWHQHAUAXRMMOT-MBANBULQSA-N |
| Smiles | O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.04 | 100 | |
| ethanol | 40.04 | 100 | |
| water | 40.04 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.5 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610 PMID: 17347320
Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174 PMID: 16570913
Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis PMID: 22216416
Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954 PMID: 21799757
Keywords: Rivastigmine tartrate, supplier, acetylcholinesterase, AChE, butyrylcholinesterase, BChE, inhibitors, inhibits, ChEI, brain, penetrant, ENA713, Rivastigmine, tartrate, ENA, 713, Cholinesterases, Cholinesterases, Tocris Bioscience
