Biological Activity
Positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).
Technical Data
| M. Wt | 283.32 |
| Formula | C17H17NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 302841-86-7 |
| PubChem ID | 9903898 |
| InChI Key | ILSZPWZFQHSKLW-UHFFFAOYSA-N |
| Smiles | O=C(NC(OCC)=O)C(C2=CC=CC=C2)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.33 | 100 | |
| ethanol | 28.33 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 283.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.65 mL | 35.3 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402 PMID: 11606768
Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124
Brock et al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000 PMID: 17855348
Keywords: Ro 01-6128, supplier, Ro01-6128, metabotropic, glutamate, mglu1, mglur1, pam, positive, allosteric, modulators, potentiators, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
