Tocris/Ro 08-2750/2272/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Ro 08-2750/2272/50/50 mg

Tocris/Ro 08-2750/2272/50/50 mg

商品编号： 2272/50

品牌： Tocris Bioscience

市场价： ¥15100.00

美元价： 9060.00

产地：美国(厂家直采)

公司：

产品分类：激酶

公司分类： kinase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:InhibitsNGFbindingtop75^NTRandTrkA

ChemicalName:2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Non-peptideinhibitorofNGFthatbindstheNGFdimer(K_D~1μM)possIBLycausingaconformationalchange.SelectivelyinhibitsbindingofNGFtop75^NTRatsubmicromolarconcentrations,andtobothp75^NTRandTrkAatconcentrations>5μM.PreventsNGF-inducedapoptosisinSK-N-MCcells.

TechnicalData

M.Wt	270.24
Formula	C₁₃H₁₀N₄O₃
Storage	Storeat-20°C
Purity	≥95%(HPLC)
CASNumber	37854-59-4
PubChemID	17756791
InChIKey	JDEMVNYMYPJJIM-UHFFFAOYSA-N
Smiles	CN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.NaOH	13.51	50
	DMSO	2.7	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight270.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.7mL	18.5mL	37mL
5mM	0.74mL	3.7mL	7.4mL
10mM	0.37mL	1.85mL	3.7mL
50mM	0.07mL	0.37mL	0.74mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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