Biological Activity
Selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
Compound Libraries
Ro 10-5824 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 353.29 |
| Formula | C17H20N4.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 189744-94-3 |
| PubChem ID | 16759174 |
| InChI Key | UZHMRJRDYCRKIZ-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CC1=NC=C(CN2CCC(=CC2)C2=CC=CC=C2)C(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.5 | 75 | |
| water | 35.33 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 353.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.15 mL | 28.31 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Powell et al (2003) RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 473 PMID: 12646284
Keywords: Ro 10-5824 dihydrochloride, supplier, Selective, D4, receptor, partial, agonists, Dopamine, Receptors, dopaminergic, Ro10-5824, dihydrochloride, D4, Receptors, D4, Receptors, Tocris Bioscience
