BiologicalActivity
InhibitorofNF-κBactivation,possIBLyviaselectiveinhibitionofLPS-andTNF-α-inducedIκBαubiquitination(IC50=3μM).BlockssubsequentproductionofTNF-α,IL-1βandIL-6.InhibitsmucinproductioninaninvitromodelofCOPD,andisanti-inflammatoryfollowingoraladmiNISTrationinvivo.AlsoweaklyinhibitsEGFR,5-lipoxygenaseandiNOS.
CompoundLibraries
Ro106-9920isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 245.26 |
Formula | C10H7N5OS |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 62645-28-7 |
PubChemID | 3906779 |
InChIKey | JFSXSNSCPNFCDM-UHFFFAOYSA-N |
Smiles | O=S(C1=CC=CC=C1)C1=NN2N=NN=C2C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.53 | 100 | |
ethanol | 1.23 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight245.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.08mL | 20.39mL | 40.77mL |
5mM | 0.82mL | 4.08mL | 8.15mL |
10mM | 0.41mL | 2.04mL | 4.08mL |
50mM | 0.08mL | 0.41mL | 0.82mL |