BiologicalActivity
InhibitorofNF-κBactivation,possIBLyviaselectiveinhibitionofLPS-andTNF-α-inducedIκBαubiquitination(IC50=3μM).BlockssubsequentproductionofTNF-α,IL-1βandIL-6.InhibitsmucinproductioninaninvitromodelofCOPD,andisanti-inflammatoryfollowingoraladmiNISTrationinvivo.AlsoweaklyinhibitsEGFR,5-lipoxygenaseandiNOS.
CompoundLibraries
Ro106-9920isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 245.26 |
| Formula | C10H7N5OS |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 62645-28-7 |
| PubChemID | 3906779 |
| InChIKey | JFSXSNSCPNFCDM-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=CC=C1)C1=NN2N=NN=C2C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.53 | 100 | |
| ethanol | 1.23 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight245.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.08mL | 20.39mL | 40.77mL |
| 5mM | 0.82mL | 4.08mL | 8.15mL |
| 10mM | 0.41mL | 2.04mL | 4.08mL |
| 50mM | 0.08mL | 0.41mL | 0.82mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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