Biological Activity
Selective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
Technical Data
| M. Wt | 352.26 |
| Formula | C17H19Cl2N3O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 246852-46-0 |
| PubChem ID | 10428048 |
| InChI Key | STCVFKBRXOEQRF-YBEGLDIGSA-N |
| Smiles | ClC1=CC=CC(Cl)=C1/C(OC3CCCCCC3)=C/N2N=CN=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.23 | 100 | |
| ethanol | 35.23 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 352.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.39 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kolczewski et al (1999) Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 9 2173 PMID: 10465539
Brauner-Osbourne et al (2007) Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 8 169 PMID: 17266540
Keywords: Ro 64-5229, supplier, Ro64-5229, mGluR2, mGlu2, group, II, metabotropic, glutamate, receptor, antagonist, antagonists, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
