Biological Activity
NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).
Technical Data
| M. Wt | 406.88 |
| Formula | C21H23FN2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1312991-77-7 |
| PubChem ID | 11957680 |
| InChI Key | MQOXWHKUQOFFJW-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCC(O)CN2CCC(C3=CC=C(F)C=C3)=CC2)C=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.69 | 100 | |
| water | 4.07 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 406.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.29 mL | 24.58 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463 PMID: 9504387
Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17 PMID: 9729614
Keywords: Ro 8-4304 hydrochloride, supplier, NR2B, selective, antagonists, NMDA, Receptors, Glutamate, Ionotropic, N-Methyl-D-Aspartate, iGluR, Ro8-4304, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
