Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram and (S)-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).
Compound Libraries
Rolipram is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 275.35 |
| Formula | C16H21NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 61413-54-5 |
| PubChem ID | 5092 |
| InChI Key | HJORMJIFDVBMOB-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1OC1CCCC1)C1CNC(=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.65 | 75 | |
| ethanol | 20.65 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 275.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 5 mM | 0.73 mL | 3.63 mL | 7.26 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.63 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kato et al (1995) Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol. 272 107 PMID: 7713141
O'Donnell (1993) Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther. 264 1168 PMID: 8383740
Teixeira et al (1997) Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci. 18 164 PMID: 9184477
Keywords: Rolipram, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
