Biological Activity
Selective D2-like receptor agonist (D3 > D2 > D4). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.
Technical Data
| M. Wt | 296.84 |
| Formula | C16H24N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 91374-20-8 |
| PubChem ID | 68727 |
| InChI Key | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
| Smiles | O=C2NC1=CC=CC(CCN(CCC)CCC)=C1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.84 | 50 | |
| water | 29.68 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 296.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.84 mL | 33.69 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.74 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Eden et al (1991) Preclinical pharmacology of Ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol.Biochem.Behav. 38 147 PMID: 1673248
Tulloch (1997) Pharmacologic profile of ropinirole: a nonergoline dopamine agonist. Neurology 49 S58 PMID: 9222275
Keywords: Ropinirole, supplier, Selective, D2-like, agonists, non-selective, dopamine, receptors, dopaminergic, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
