Biological Activity
Potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Orally bioavailable.
Technical Data
| M. Wt | 500.57 |
| Formula | C22H27FN3O6S.½Ca |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 147098-20-2 |
| PubChem ID | 5282455 |
| InChI Key | LALFOYNTGMUKGG-BGRFNVSISA-L |
| Smiles | CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.06 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
McTaggart et al (2001) Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 87 28B PMID: 11256847
Keywords: Rosuvastatin calcium, supplier, ZD4522, HMG, CoA, reductase, inhibitors, inhibits, statins, 3-hydroxy-3-methyl-glutaryl-CoA, orally, bioavailable, HMG-CoA, Reductase, HMG-CoA, Reductase, Tocris Bioscience
