Biological Activity
RuBi-caged version of serotonin (Cat. No. 3547). Excited by visible wavelengths (450 nm). Has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907 (Cat. No. 4173).
Licensing Information
Sold under licence from Columbia University
Technical Data
| M. Wt | 955.66 |
| Formula | C33H37F12N6OP3Ru |
| Storage | Store at -20°C |
| PubChem ID | 91826073 |
| InChI Key | CNCGWUINLFSMHP-UHFFFAOYSA-N |
| Smiles | [Ru++].CP(C)C.F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.NCCC1=CNC2=C1C=C(O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility
Please refer to these solubility guidelines for RuBi-5-HT (Cat.No. 3856).
Preparing Stock Solutions
The following data is based on the product molecular weight 955.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.05 mL | 5.23 mL | 10.46 mL |
| 5 mM | 0.21 mL | 1.05 mL | 2.09 mL |
| 10 mM | 0.1 mL | 0.52 mL | 1.05 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.21 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Zayat et al (2006) Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines. Inorg. Chem. 45 1728 PMID: 16471986
Cabrera et al (2017) A visible-light-sensitive caged serotonin. ACS Chem.Neurosci. 8 1036 PMID: 28460173
Keywords: RuBi-5-HT, supplier, caged, serotonin, compounds, neurotransmitters, 5-HT, receptors, serotonergic, Non-selective, 5-HT, Caged, 5HT, Compounds, Non-selective, 5-HT, Tocris Bioscience
