Biological Activity
RuBi-caged dopamine (Cat. No. 3548); exhibits two-photon sensitivity. Enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Does not display phototoxicity at a concentration of 300 μM.
Licensing Information
Sold under licence from Columbia University
Technical Data
| M. Wt | 713.6 |
| Formula | C31H36Cl2N5O2PRu |
| Storage | Store at -20°C |
| PubChem ID | 90488992 |
| InChI Key | FPJFHIJODNWCIM-UHFFFAOYSA-L |
| Smiles | [Cl-].[Cl-].[Ru++].CP(C)C.NCCC1=CC=C(O)C(O)=C1.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.27 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 713.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.4 mL | 7.01 mL | 14.01 mL |
| 5 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 10 mM | 0.14 mL | 0.7 mL | 1.4 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Araya et al (2013) Two-photon optical interrogation of individual dendritic spines with caged dopamine. ACS Chem. Neurosci. [Epub ahead of print] PMID: 23672485
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