Biological Activity
Ruthenium-bisbipyridine-caged nicotine, excitable by irradiation with visible light. Undergoes rapid photolysis to release nicotine (< 20 ns); exhibits a high quantum yield. Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1 mM.
Licensing Information
Sold under licence from Columbia University
Technical Data
| M. Wt | 808.81 |
| Formula | C40H44Cl2N8Ru |
| Storage | Store at -20°C |
| CAS Number | 1256362-30-7 |
| PubChem ID | 90488888 |
| InChI Key | DRYNYXIOLIUZSG-ZPFSJBFKSA-L |
| Smiles | [Cl-].[Cl-].[Ru++].C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.[H][C@]1(CCCN1C)C1=CC=CN=C1.[H][C@]1(CCCN1C)C1=CC=CN=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 40.44 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 808.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.24 mL | 6.18 mL | 12.36 mL |
| 5 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 10 mM | 0.12 mL | 0.62 mL | 1.24 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.25 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Filevich et al (2010) A caged nicotine with nanosecond range kinetics and visible light sensitivity. J.Inorg.Biochem. 104 1248 PMID: 20825994
Keywords: RuBi-Nicotine, supplier, RuBiNicotine, caged, compounds, nicotinics, cholinergics, acetylcholine, receptors, nAChRs, agonist, excitatory, Nicotinic, Receptors, (Non-selective), Other, Caged, Compounds, Nicotinic, Receptors, (Non-selective), Tocris Bioscience
