Biological Activity
Modified version of RuBi-GABA (Cat. No. 3400). Suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse; inhibits neural activity.
Licensing Information
Sold under licence from Columbia University
Technical Data
| M. Wt | 904.56 |
| Formula | C27H33N5O2PRu.PF6.NaPF6 |
| Storage | Store at -20°C |
| PubChem ID | 66552906 |
| InChI Key | BNALUYKEGYUHQC-UHFFFAOYSA-N |
| Smiles | C[P]([Ru+2]12([N]3=CC=CC=C3C4=[N]1C=CC=C4)([N]5=CC=CC=C5C6=CC=CC=[N]62)[NH2]CCCC([O-])=O)(C)C.F[P-](F)(F)(F)(F)F.[Na]P(F)(F)(F)(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.08 | 40 |
Preparing Stock Solutions
The following data is based on the product molecular weight 904.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.11 mL | 5.53 mL | 11.06 mL |
| 5 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.11 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lopes-dos-Santos et al (2011) In vivo photorelease of GABA in the mouse cortex. Braz.J.Med.Biol.Res. 44 688 PMID: 21755263
Filevich et al (2013) RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity. Photochem.Photobiol.Sci. 12 1565 PMID: 23674097
Keywords: RuBi GABA trimethylphosphine, supplier, RuBi, GABA, caged, agonists, RUBIGABA2, RUBIGABA-2, RuBi-GABA-PMe3, GABAB, Receptors, GABAA, Receptors, GABAA-rho, Receptors, Miscellaneous, GABA, Caged, GABA, Compounds, GABAB, Receptors, Tocris Bioscience
