Biological Activity
Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.
Technical Data
| M. Wt | 238.19 |
| Formula | C10H8F2N4O |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 106308-44-5 |
| PubChem ID | 129228 |
| InChI Key | POGQSBRIGCQNEG-UHFFFAOYSA-N |
| Smiles | O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.82 | 100 | |
| ethanol | 1.19 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 238.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.2 mL | 20.99 mL | 41.98 mL |
| 5 mM | 0.84 mL | 4.2 mL | 8.4 mL |
| 10 mM | 0.42 mL | 2.1 mL | 4.2 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273 PMID: 16621450
Arroyo (2007) Rufinamide. Neurotherapeutics 4 155 PMID: 17199032
White et al (2008) The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia 49 1213 PMID: 18325020
Keywords: Rufinamide, supplier, CGP33101, sodium, channels, voltage-gated, voltage-dependent, NaV, Na+, prolongs, inactivation, anticonvulsant, anticonvulsive, antiepileptic, CGP, 33101, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
