Biological Activity
Potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.
Compound Libraries
S 18886 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 407.91 |
| Formula | C20H22ClNO4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 165538-40-9 |
| PubChem ID | 9938840 |
| InChI Key | HWEOXFSBSQIWSY-MRXNPFEDSA-N |
| Smiles | CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.79 | 100 | |
| ethanol | 8.16 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 407.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.26 mL | 24.52 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375 PMID: 9871769
Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015 PMID: 25221659
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