Biological Activity
Positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.
Technical Data
| M. Wt | 224.28 |
| Formula | C10H12N2O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 175340-20-2 |
| PubChem ID | 637863 |
| InChI Key | MNTIJYGEITVWHU-SNVBAGLBSA-N |
| Smiles | O=S2(C1=CC=CC=C1N(CCC3)[C@@]3([H])N2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 224.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.46 mL | 22.29 mL | 44.59 mL |
| 5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.89 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Desos et al (1996) Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator. Bioorg.Med.Chem.Lett. 6 3003 PMID:
Lockhart et al (2000) (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. Eur.J.Pharmacol. 401 145 PMID: 10924919
Bourasset et al (2005) Neuropharmacokinetics of a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab.Dispos. 33 1137 PMID: 15860654
Keywords: S 18986, supplier, S18986, pam, positive, allosteric, modulators, potentiators, ampa, cognitive, enhancers, enhancement, brain, penetrant, bbb, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
