Biological Activity
LSD1 inhibitor (IC50 = 990 nM; Ki = 610 nM). Exhibits selectivity for LSD1 over MAO-B and MAO-A (Ki values are 17 and 110 μM, respectively).
Technical Data
| M. Wt | 311.75 |
| Formula | C16H15F2NO.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1239262-36-2 |
| PubChem ID | 121513887 |
| InChI Key | CTSUZAFTJVLOIX-SBKWZQTDSA-N |
| Smiles | FC1=CC([C@@H]2C[C@H]2N)=C(OCC3=CC=CC=C3)C(F)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.18 | 100 | |
| water | 15.59 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 311.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.21 mL | 16.04 mL | 32.08 mL |
| 5 mM | 0.64 mL | 3.21 mL | 6.42 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.21 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Mimasu et al (2010) Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 49 6494 PMID: 20568732
Keywords: S 2101, supplier, S2101, LSD1, inhibitors, inhibits, histones, demethylases, KDM1, Histone, Demethylases, Histone, Demethylases, Tocris Bioscience
